Drug interactions
Frovatriptan + Sufentanil sl
Severity: Moderate
Frovatriptan and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as sufentanil have been associated with serotonin syndrome when combined with triptans, though the risk is considered low. The combination could cause agitation, clonus, hyperthermia and autonomic instability.
What this interaction means in plain words
Frovatriptan and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic neurotransmission; mechanism for opioids not firmly established.
What to do
Observe closely during initiation and dose changes for signs of serotonin syndrome. Stop treatment and give supportive care if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Sufentanil sl?
MediHelp rates the interaction as moderate. Frovatriptan and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids such as sufentanil have been associated with serotonin syndrome when combined with triptans, though the risk is considered low. The combination could cause agitation, clonus, hyperthermia and autonomic instability.
How serious is the interaction between Frovatriptan and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe closely during initiation and dose changes for signs of serotonin syndrome. Stop treatment and give supportive care if symptoms develop.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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