Drug interactions
Frovatriptan + Sumatriptan intranasal
Severity: Contraindicated
Frovatriptan and Sumatriptan intranasal: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two triptans close together produces additive vasoconstriction and raises the risk of coronary or peripheral vasospasm. There is no established advantage to combining them.
What this interaction means in plain words
Frovatriptan and Sumatriptan intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive 5-HT1B/1D receptor agonism causing vasoconstriction.
What to do
Do not give two triptans within 24 hours. Use one agent per attack.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Sumatriptan intranasal?
MediHelp rates the interaction as contraindicated. Frovatriptan and Sumatriptan intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Using two triptans close together produces additive vasoconstriction and raises the risk of coronary or peripheral vasospasm. There is no established advantage to combining them.
How serious is the interaction between Frovatriptan and Sumatriptan intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give two triptans within 24 hours. Use one agent per attack.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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