Drug interactions
Frovatriptan + Trifluoperazine
Severity: Moderate
Frovatriptan and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine is a phenothiazine that blocks dopamine receptors. Combined with frovatriptan, serotonin syndrome or neuroleptic malignant syndrome is theoretically possible, though cases are rare.
What this interaction means in plain words
Frovatriptan and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Serotonergic modulation with dopamine D2 antagonism; theoretical.
What to do
Monitor for hyperthermia, rigidity, agitation and autonomic instability when starting or adjusting either drug. Stop the agents and treat if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Trifluoperazine?
MediHelp rates the interaction as moderate. Frovatriptan and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine is a phenothiazine that blocks dopamine receptors. Combined with frovatriptan, serotonin syndrome or neuroleptic malignant syndrome is theoretically possible, though cases are rare.
How serious is the interaction between Frovatriptan and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hyperthermia, rigidity, agitation and autonomic instability when starting or adjusting either drug. Stop the agents and treat if toxicity occurs.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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