Drug interactions
Gabapentin + Imipramine
Severity: Moderate
Gabapentin and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and dizziness, so together they can increase CNS depression. Respiratory depression is a concern mainly in elderly patients, those with lung disease, or when opioids are also used.
What this interaction means in plain words
Gabapentin and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through different pharmacodynamic pathways.
What to do
Start with low doses and titrate slowly; monitor for sedation, falls and respiratory depression, especially if other CNS depressants are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Imipramine?
MediHelp rates the interaction as moderate. Gabapentin and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and dizziness, so together they can increase CNS depression. Respiratory depression is a concern mainly in elderly patients, those with lung disease, or when opioids are also used.
How serious is the interaction between Gabapentin and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate slowly; monitor for sedation, falls and respiratory depression, especially if other CNS depressants are present.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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