Drug interactions
Gabapentin + Paroxetine
Severity: Minor
Gabapentin and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness, and together they may add to sedation and psychomotor impairment. Serious respiratory depression is uncommon but possible, mainly with other CNS depressants or in vulnerable patients.
What this interaction means in plain words
Gabapentin and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gabapentin belongs to Central Nervous System; Paroxetine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Use the lowest effective gabapentin dose and monitor for sedation, particularly in elderly patients or those with respiratory disease. Advise caution when driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Paroxetine?
MediHelp rates the interaction as minor. Gabapentin and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause drowsiness and dizziness, and together they may add to sedation and psychomotor impairment. Serious respiratory depression is uncommon but possible, mainly with other CNS depressants or in vulnerable patients.
How serious is the interaction between Gabapentin and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective gabapentin dose and monitor for sedation, particularly in elderly patients or those with respiratory disease. Advise caution when driving.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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