Drug interactions
Gabapentin + Phenelzine
Severity: Moderate
Gabapentin and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin causes sedation and dizziness, and phenelzine may add to CNS depression. The combination can increase drowsiness and impair alertness, with rare respiratory depression in vulnerable patients.
What this interaction means in plain words
Gabapentin and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through pharmacodynamic synergism.
What to do
Start gabapentin low and titrate slowly, monitoring for oversedation and respiratory depression. Counsel about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Phenelzine?
MediHelp rates the interaction as moderate. Gabapentin and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin causes sedation and dizziness, and phenelzine may add to CNS depression. The combination can increase drowsiness and impair alertness, with rare respiratory depression in vulnerable patients.
How serious is the interaction between Gabapentin and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start gabapentin low and titrate slowly, monitoring for oversedation and respiratory depression. Counsel about driving and alcohol.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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