Drug interactions
Gabapentin + Suvorexant
Severity: Moderate
Gabapentin and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Suvorexant is an orexin receptor antagonist hypnotic that causes somnolence. With gabapentin, sedation and next-day impairment may be increased.
What this interaction means in plain words
Gabapentin and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Use the lowest effective suvorexant dose and warn about next-day drowsiness and impaired driving. Monitor for excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gabapentin and Suvorexant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Gabapentin
Other interactions of Suvorexant
Frequently asked questions
Can I take Gabapentin with Suvorexant?
MediHelp rates the interaction as moderate. Gabapentin and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Suvorexant is an orexin receptor antagonist hypnotic that causes somnolence. With gabapentin, sedation and next-day impairment may be increased.
How serious is the interaction between Gabapentin and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective suvorexant dose and warn about next-day drowsiness and impaired driving. Monitor for excessive sedation.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
