Drug interactions
Gabapentin + Zuranolone
Severity: Moderate
Gabapentin and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes somnolence and psychomotor impairment, and gabapentin adds further sedation and dizziness. The combination can increase CNS depression and impair driving ability.
What this interaction means in plain words
Gabapentin and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excessive sedation and consider reducing the zuranolone dose if the combination is necessary. Advise patients not to drive for at least 12 hours after each zuranolone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gabapentin
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Gabapentin with Zuranolone?
MediHelp rates the interaction as moderate. Gabapentin and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes somnolence and psychomotor impairment, and gabapentin adds further sedation and dizziness. The combination can increase CNS depression and impair driving ability.
How serious is the interaction between Gabapentin and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider reducing the zuranolone dose if the combination is necessary. Advise patients not to drive for at least 12 hours after each zuranolone dose.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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