Drug interactions
Galantamine + Indinavir
Severity: Moderate
Galantamine and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a CYP3A4 inhibitor and may raise galantamine levels. Higher exposure could intensify cholinergic effects such as bradycardia, nausea and vomiting.
What this interaction means in plain words
Galantamine and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated galantamine metabolism by indinavir.
What to do
Monitor heart rate and gastrointestinal tolerability, and lower the galantamine dose if cholinergic effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Indinavir?
MediHelp rates the interaction as moderate. Galantamine and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is a CYP3A4 inhibitor and may raise galantamine levels. Higher exposure could intensify cholinergic effects such as bradycardia, nausea and vomiting.
How serious is the interaction between Galantamine and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and gastrointestinal tolerability, and lower the galantamine dose if cholinergic effects develop.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Physostigmine, Ponesimod. The full list is on the Galantamine page.
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