Drug interactions
Galantamine + Isoniazid
Severity: Minor
Galantamine and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Galantamine is metabolized by CYP2D6 and CYP3A4, and isoniazid might slightly reduce its clearance. Cholinergic effects such as nausea, bradycardia and vomiting could be increased. The effect is expected to be small.
What this interaction means in plain words
Galantamine and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Galantamine belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak CYP3A4 inhibition by isoniazid may raise galantamine concentrations.
What to do
Monitor heart rate and gastrointestinal tolerance. Reduce the galantamine dose if cholinergic effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Isoniazid?
MediHelp rates the interaction as minor. Galantamine and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Galantamine is metabolized by CYP2D6 and CYP3A4, and isoniazid might slightly reduce its clearance. Cholinergic effects such as nausea, bradycardia and vomiting could be increased. The effect is expected to be small.
How serious is the interaction between Galantamine and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and gastrointestinal tolerance. Reduce the galantamine dose if cholinergic effects occur.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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