Drug interactions
Galantamine + Lumefantrine
Severity: Minor
Galantamine and Lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine inhibits CYP2D6 and may raise galantamine exposure modestly. This could increase cholinergic effects such as nausea, vomiting, bradycardia and dizziness.
What this interaction means in plain words
Galantamine and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP2D6-mediated galantamine metabolism by lumefantrine.
What to do
Usually no dose change is needed; monitor heart rate and gastrointestinal tolerance during the antimalarial course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Lumefantrine?
MediHelp rates the interaction as minor. Galantamine and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine inhibits CYP2D6 and may raise galantamine exposure modestly. This could increase cholinergic effects such as nausea, vomiting, bradycardia and dizziness.
How serious is the interaction between Galantamine and Lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no dose change is needed; monitor heart rate and gastrointestinal tolerance during the antimalarial course.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Physostigmine, Ponesimod. The full list is on the Galantamine page.
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