Drug interactions
Galantamine + Phenytoin
Severity: Minor
Galantamine and Phenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces CYP3A4 and may lower galantamine concentrations, potentially reducing its effect. The magnitude is uncertain, as galantamine is also cleared by CYP2D6 and renally.
What this interaction means in plain words
Galantamine and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Galantamine belongs to Central Nervous System; Phenytoin belongs to Central Nervous System.
Why it happens
CYP3A4 induction by phenytoin increases galantamine clearance.
What to do
Monitor cognitive response and titrate galantamine within the approved range if benefit diminishes. Reassess if phenytoin is discontinued.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Galantamine with Phenytoin?
MediHelp rates the interaction as minor. Galantamine and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenytoin induces CYP3A4 and may lower galantamine concentrations, potentially reducing its effect. The magnitude is uncertain, as galantamine is also cleared by CYP2D6 and renally.
How serious is the interaction between Galantamine and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognitive response and titrate galantamine within the approved range if benefit diminishes. Reassess if phenytoin is discontinued.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Physostigmine, Ponesimod. The full list is on the Galantamine page.
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