Drug interactions
Galantamine + Rapacuronium
Severity: Moderate
Galantamine and Rapacuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholinesterase inhibitors such as galantamine may antagonize non-depolarizing neuromuscular blockade, shortening or reducing the effect of rapacuronium. Rapacuronium has been withdrawn from most markets owing to bronchospasm.
What this interaction means in plain words
Galantamine and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased acetylcholine at the neuromuscular junction opposes competitive blockade.
What to do
Monitor neuromuscular function with a nerve stimulator during anaesthesia and adjust the blocker dose; inform the anaesthetist about galantamine use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Rapacuronium?
MediHelp rates the interaction as moderate. Galantamine and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholinesterase inhibitors such as galantamine may antagonize non-depolarizing neuromuscular blockade, shortening or reducing the effect of rapacuronium. Rapacuronium has been withdrawn from most markets owing to bronchospasm.
How serious is the interaction between Galantamine and Rapacuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator during anaesthesia and adjust the blocker dose; inform the anaesthetist about galantamine use.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Physostigmine, Ponesimod. The full list is on the Galantamine page.
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