Drug interactions
Ganaxolone + Ketamine
Severity: Moderate
Ganaxolone and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so using them together can deepen sedation and impair alertness and psychomotor performance. The effect is most relevant when ketamine is given at anesthetic or analgesic doses.
What this interaction means in plain words
Ganaxolone and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Ketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A positive modulation by ganaxolone combined with NMDA antagonism by ketamine.
What to do
Monitor level of sedation and respiratory status when the two are given together. Consider lowering the dose of either drug if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Ketamine?
MediHelp rates the interaction as moderate. Ganaxolone and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so using them together can deepen sedation and impair alertness and psychomotor performance. The effect is most relevant when ketamine is given at anesthetic or analgesic doses.
How serious is the interaction between Ganaxolone and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor level of sedation and respiratory status when the two are given together. Consider lowering the dose of either drug if excessive drowsiness occurs.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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