Drug interactions
Ganaxolone + Remifentanil
Severity: Moderate
Ganaxolone and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a sedating neuroactive steroid, and remifentanil is a potent opioid. Used together they can produce additive sedation, respiratory depression and impaired psychomotor function.
What this interaction means in plain words
Ganaxolone and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression from opioid receptor agonism and GABA-A receptor modulation.
What to do
Monitor sedation level and respiratory rate and titrate remifentanil to the lowest effective rate. Reduce doses of either agent if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Remifentanil?
MediHelp rates the interaction as moderate. Ganaxolone and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a sedating neuroactive steroid, and remifentanil is a potent opioid. Used together they can produce additive sedation, respiratory depression and impaired psychomotor function.
How serious is the interaction between Ganaxolone and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory rate and titrate remifentanil to the lowest effective rate. Reduce doses of either agent if excessive sedation occurs.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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