Drug interactions
Ganciclovir + Hydrochlorothiazide-valsartan
Severity: Minor
Ganciclovir and Hydrochlorothiazide-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganciclovir is cleared mostly by the kidneys including tubular secretion, so any reduction in renal clearance can increase exposure and hematologic toxicity. Volume depletion from the diuretic may add to this.
What this interaction means in plain words
Ganciclovir and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ganciclovir belongs to Anti Virals; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Possible competition for tubular secretion and diuretic-related reduction in renal clearance.
What to do
Monitor renal function and blood counts during ganciclovir therapy. Adjust the ganciclovir dose to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Ganciclovir
Frequently asked questions
Can I take Ganciclovir with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as minor. Ganciclovir and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ganciclovir is cleared mostly by the kidneys including tubular secretion, so any reduction in renal clearance can increase exposure and hematologic toxicity. Volume depletion from the diuretic may add to this.
How serious is the interaction between Ganciclovir and Hydrochlorothiazide-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts during ganciclovir therapy. Adjust the ganciclovir dose to creatinine clearance.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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