Drug interactions
Ganciclovir + Ifosfamide
Severity: Moderate
Ganciclovir and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide and ganciclovir are both myelosuppressive, so combined use raises the risk of severe cytopenias. Ifosfamide can also cause renal toxicity, which may further increase ganciclovir exposure.
What this interaction means in plain words
Ganciclovir and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganciclovir belongs to Anti Virals; Ifosfamide belongs to Oncology.
Why it happens
Additive myelosuppression, with possible reduced ganciclovir clearance from ifosfamide nephrotoxicity.
What to do
Monitor blood counts and renal function closely, and adjust the ganciclovir dose to creatinine clearance. Delay or reduce doses for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ganciclovir and Ifosfamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ganciclovir
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ganciclovir with Ifosfamide?
MediHelp rates the interaction as moderate. Ganciclovir and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide and ganciclovir are both myelosuppressive, so combined use raises the risk of severe cytopenias. Ifosfamide can also cause renal toxicity, which may further increase ganciclovir exposure.
How serious is the interaction between Ganciclovir and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function closely, and adjust the ganciclovir dose to creatinine clearance. Delay or reduce doses for significant cytopenias.
What other medicines interact with Ganciclovir?
MediHelp also lists interactions of Ganciclovir with, for example, Bacitracin, Cilastatin-imipenem, Didanosine. The full list is on the Ganciclovir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
