Drug interactions
Garlic + Indinavir
Severity: Moderate
Garlic and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Garlic supplements may reduce plasma levels of some protease inhibitors. Lower indinavir exposure could compromise HIV suppression.
What this interaction means in plain words
Garlic and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible induction of CYP3A4 or transporters by garlic constituents; the mechanism is not clearly established.
What to do
Advise avoiding garlic supplements during indinavir therapy. Monitor viral load if supplements are taken.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Garlic
- Garlic + Saquinavir Major
- Aceclofenac + Garlic Moderate
- Acemetacin + Garlic Moderate
- Aescin + Garlic Moderate
- Alteplase + Garlic Moderate
- Argatroban + Garlic Moderate
Frequently asked questions
Can I take Garlic with Indinavir?
MediHelp rates the interaction as moderate. Garlic and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Garlic supplements may reduce plasma levels of some protease inhibitors. Lower indinavir exposure could compromise HIV suppression.
How serious is the interaction between Garlic and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding garlic supplements during indinavir therapy. Monitor viral load if supplements are taken.
What other medicines interact with Garlic?
MediHelp also lists interactions of Garlic with, for example, Saquinavir, Aceclofenac, Acemetacin. The full list is on the Garlic page.
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