Drug interactions
Garlic + Ketorolac intranasal
Severity: Moderate
Garlic and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac inhibits platelet function even by the intranasal route, and garlic also has antiplatelet effects. Together they may increase bleeding risk, especially in surgical patients or those with GI risk factors.
What this interaction means in plain words
Garlic and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects, with ketorolac causing COX-1 inhibition and garlic inhibiting platelet aggregation by other pathways.
What to do
Advise patients to avoid garlic supplements while using ketorolac and to stop them before surgery. Monitor for bleeding, including GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Garlic
- Garlic + Saquinavir Major
- Aceclofenac + Garlic Moderate
- Acemetacin + Garlic Moderate
- Aescin + Garlic Moderate
- Alteplase + Garlic Moderate
- Argatroban + Garlic Moderate
Frequently asked questions
Can I take Garlic with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Garlic and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac inhibits platelet function even by the intranasal route, and garlic also has antiplatelet effects. Together they may increase bleeding risk, especially in surgical patients or those with GI risk factors.
How serious is the interaction between Garlic and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid garlic supplements while using ketorolac and to stop them before surgery. Monitor for bleeding, including GI bleeding.
What other medicines interact with Garlic?
MediHelp also lists interactions of Garlic with, for example, Saquinavir, Aceclofenac, Acemetacin. The full list is on the Garlic page.
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