Drug interactions
Gefitinib + Lansoprazole
Severity: Major
Gefitinib and Lansoprazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gefitinib needs an acidic stomach for adequate dissolution, and sustained gastric pH elevation lowers gefitinib exposure. This may compromise its efficacy in EGFR-mutant lung cancer.
What this interaction means in plain words
Gefitinib and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gefitinib belongs to Oncology; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Gastric pH elevation reduces gefitinib solubility and absorption.
What to do
Avoid PPIs if possible. If a PPI is essential, give gefitinib 12 hours after the PPI dose, though acid-reducing effects may persist.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Gefitinib
Frequently asked questions
Can I take Gefitinib with Lansoprazole?
MediHelp rates the interaction as major. Gefitinib and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gefitinib needs an acidic stomach for adequate dissolution, and sustained gastric pH elevation lowers gefitinib exposure. This may compromise its efficacy in EGFR-mutant lung cancer.
How serious is the interaction between Gefitinib and Lansoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs if possible. If a PPI is essential, give gefitinib 12 hours after the PPI dose, though acid-reducing effects may persist.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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