Drug interactions
Dexlansoprazole + Gefitinib
Severity: Major
Dexlansoprazole and Gefitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gefitinib needs an acidic stomach for adequate absorption, and acid suppression with a PPI lowers its exposure markedly. This may reduce anticancer efficacy.
What this interaction means in plain words
Dexlansoprazole and Gefitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexlansoprazole belongs to Gastrointestinal Tract; Gefitinib belongs to Oncology.
Why it happens
Increased gastric pH reduces gefitinib solubility and absorption.
What to do
Avoid PPIs if possible. If one is required, take gefitinib 12 hours after the PPI dose, though this may not fully prevent the effect.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Gefitinib
- Apalutamide + Gefitinib Major
- Carbamazepine + Gefitinib Major
- Esomeprazole + Gefitinib Major
- Gefitinib + Lansoprazole Major
- Gefitinib + Omeprazole Major
- Gefitinib + Pantoprazole Major
Frequently asked questions
Can I take Dexlansoprazole with Gefitinib?
MediHelp rates the interaction as major. Dexlansoprazole and Gefitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gefitinib needs an acidic stomach for adequate absorption, and acid suppression with a PPI lowers its exposure markedly. This may reduce anticancer efficacy.
How serious is the interaction between Dexlansoprazole and Gefitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs if possible. If one is required, take gefitinib 12 hours after the PPI dose, though this may not fully prevent the effect.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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