Drug interactions
Gemtuzumab + Isoflurane
Severity: Moderate
Gemtuzumab and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemtuzumab ozogamicin has been associated with QT prolongation, and isoflurane can also lengthen the QT interval. Combined exposure may raise the risk of torsades de pointes, particularly with electrolyte abnormalities.
What this interaction means in plain words
Gemtuzumab and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization.
What to do
Check ECG and electrolytes before anesthesia and correct potassium and magnesium. Monitor the QTc perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gemtuzumab and Isoflurane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Isoflurane
Frequently asked questions
Can I take Gemtuzumab with Isoflurane?
MediHelp rates the interaction as moderate. Gemtuzumab and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemtuzumab ozogamicin has been associated with QT prolongation, and isoflurane can also lengthen the QT interval. Combined exposure may raise the risk of torsades de pointes, particularly with electrolyte abnormalities.
How serious is the interaction between Gemtuzumab and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before anesthesia and correct potassium and magnesium. Monitor the QTc perioperatively.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
