Drug interactions
Gemtuzumab + Nilotinib
Severity: Moderate
Gemtuzumab and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemtuzumab ozogamicin has been associated with QT prolongation, and nilotinib prolongs the QT interval, so the combination may increase the risk of arrhythmia. Patients with electrolyte disturbances or cardiac disease are at greater risk.
What this interaction means in plain words
Gemtuzumab and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Perform ECG at baseline and periodically, and correct potassium and magnesium before and during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Gemtuzumab with Nilotinib?
MediHelp rates the interaction as moderate. Gemtuzumab and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemtuzumab ozogamicin has been associated with QT prolongation, and nilotinib prolongs the QT interval, so the combination may increase the risk of arrhythmia. Patients with electrolyte disturbances or cardiac disease are at greater risk.
How serious is the interaction between Gemtuzumab and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG at baseline and periodically, and correct potassium and magnesium before and during treatment.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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