Drug interactions
Gemtuzumab + Sunitinib
Severity: Moderate
Gemtuzumab and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with QT prolongation, and gemtuzumab ozogamicin labeling advises ECG monitoring with other QT-prolonging drugs. Combination may increase arrhythmia risk, and both can also cause hepatotoxicity.
What this interaction means in plain words
Gemtuzumab and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization.
What to do
Monitor ECG and electrolytes at baseline and during therapy, and monitor liver tests.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Gemtuzumab with Sunitinib?
MediHelp rates the interaction as moderate. Gemtuzumab and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been associated with QT prolongation, and gemtuzumab ozogamicin labeling advises ECG monitoring with other QT-prolonging drugs. Combination may increase arrhythmia risk, and both can also cause hepatotoxicity.
How serious is the interaction between Gemtuzumab and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and during therapy, and monitor liver tests.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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