Drug interactions
Gemtuzumab + Trastuzumab
Severity: Moderate
Gemtuzumab and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemtuzumab ozogamicin causes severe and prolonged myelosuppression, and trastuzumab with myelosuppressive therapy has been linked to more neutropenia. The combination may raise the risk of infection and bleeding.
What this interaction means in plain words
Gemtuzumab and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myelosuppression, mainly from the calicheamicin payload of gemtuzumab.
What to do
Monitor blood counts closely and for infection. Provide supportive care and adjust gemtuzumab dosing for severe cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Frequently asked questions
Can I take Gemtuzumab with Trastuzumab?
MediHelp rates the interaction as moderate. Gemtuzumab and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemtuzumab ozogamicin causes severe and prolonged myelosuppression, and trastuzumab with myelosuppressive therapy has been linked to more neutropenia. The combination may raise the risk of infection and bleeding.
How serious is the interaction between Gemtuzumab and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and for infection. Provide supportive care and adjust gemtuzumab dosing for severe cytopenias.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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