Drug interactions
Ginkgo biloba + Tolmetin
Severity: Moderate
Ginkgo biloba and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ginkgo contains ginkgolides that antagonize platelet-activating factor, and bleeding events have been reported with it. Combined with an NSAID, bleeding risk may be increased.
What this interaction means in plain words
Ginkgo biloba and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects: PAF antagonism by ginkgolides and COX inhibition by tolmetin.
What to do
Advise patients to avoid ginkgo while on tolmetin where possible. Monitor for bruising, gastrointestinal bleeding or other bleeding signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Ginkgo biloba with Tolmetin?
MediHelp rates the interaction as moderate. Ginkgo biloba and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ginkgo contains ginkgolides that antagonize platelet-activating factor, and bleeding events have been reported with it. Combined with an NSAID, bleeding risk may be increased.
How serious is the interaction between Ginkgo biloba and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid ginkgo while on tolmetin where possible. Monitor for bruising, gastrointestinal bleeding or other bleeding signs.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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