Drug interactions
Givinostat + Lithium
Severity: Moderate
Givinostat and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval and lithium may contribute additively. This raises the risk of serious ventricular arrhythmia, particularly with electrolyte disturbance or heart disease.
What this interaction means in plain words
Givinostat and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givinostat belongs to Miscellaneous; Lithium belongs to Central Nervous System.
Why it happens
Potential additive prolongation of cardiac repolarization.
What to do
Obtain an ECG at baseline, during concomitant use and as clinically indicated. Withhold givinostat if the QTc exceeds 500 ms or rises by more than 60 ms from baseline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Lithium?
MediHelp rates the interaction as moderate. Givinostat and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat can prolong the QT interval and lithium may contribute additively. This raises the risk of serious ventricular arrhythmia, particularly with electrolyte disturbance or heart disease.
How serious is the interaction between Givinostat and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline, during concomitant use and as clinically indicated. Withhold givinostat if the QTc exceeds 500 ms or rises by more than 60 ms from baseline.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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