Drug interactions
Givinostat + Metformin-sitagliptin
Severity: Minor
Givinostat and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat is a weak inhibitor of renal organic cation transport and may modestly raise metformin exposure. Higher metformin levels increase the risk of GI effects and, rarely, lactic acidosis, mainly in patients with renal impairment.
What this interaction means in plain words
Givinostat and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givinostat belongs to Miscellaneous; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Weak inhibition of renal cation transporters (OCT2) reduces metformin renal clearance.
What to do
Monitor renal function and for metformin adverse effects, and reduce the metformin dose if tolerability issues or renal decline occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Givinostat and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givinostat is a weak inhibitor of renal organic cation transport and may modestly raise metformin exposure. Higher metformin levels increase the risk of GI effects and, rarely, lactic acidosis, mainly in patients with renal impairment.
How serious is the interaction between Givinostat and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for metformin adverse effects, and reduce the metformin dose if tolerability issues or renal decline occur.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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