Drug interactions
Givinostat + Metformin
Severity: Moderate
Givinostat and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat weakly inhibits renal transporters involved in the elimination of metformin, which could modestly raise metformin exposure. Higher metformin levels increase the risk of gastrointestinal effects and, rarely, lactic acidosis.
What this interaction means in plain words
Givinostat and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givinostat belongs to Miscellaneous; Metformin belongs to Endocrine.
Why it happens
Givinostat inhibits renal organic cation transport (OCT2/related transporters), reducing the tubular secretion of metformin.
What to do
Monitor for metformin adverse effects and renal function when the drugs are combined. Reduce the metformin dose if intolerance or elevated exposure is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Metformin?
MediHelp rates the interaction as moderate. Givinostat and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat weakly inhibits renal transporters involved in the elimination of metformin, which could modestly raise metformin exposure. Higher metformin levels increase the risk of gastrointestinal effects and, rarely, lactic acidosis.
How serious is the interaction between Givinostat and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for metformin adverse effects and renal function when the drugs are combined. Reduce the metformin dose if intolerance or elevated exposure is suspected.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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