Drug interactions
Givinostat + Olanzapine
Severity: Moderate
Givinostat and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval, and olanzapine may add a small effect. Combined use may raise the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Givinostat and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givinostat belongs to Miscellaneous; Olanzapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization.
What to do
Obtain ECGs at initiation and during combined use, and correct electrolytes. Withhold givinostat if QTc becomes markedly prolonged per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Olanzapine?
MediHelp rates the interaction as moderate. Givinostat and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat can prolong the QT interval, and olanzapine may add a small effect. Combined use may raise the risk of serious ventricular arrhythmia.
How serious is the interaction between Givinostat and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECGs at initiation and during combined use, and correct electrolytes. Withhold givinostat if QTc becomes markedly prolonged per labeling.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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