Drug interactions
Givinostat + Phenytoin
Severity: Minor
Givinostat and Phenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat is a weak CYP3A4 inhibitor, but phenytoin is mainly metabolized by CYP2C9 and CYP2C19, so a meaningful rise in phenytoin is unlikely. Interaction is largely theoretical.
What this interaction means in plain words
Givinostat and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givinostat belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by givinostat; phenytoin's main metabolic pathways are not affected.
What to do
Monitor phenytoin levels and for signs of toxicity if clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Phenytoin?
MediHelp rates the interaction as minor. Givinostat and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givinostat is a weak CYP3A4 inhibitor, but phenytoin is mainly metabolized by CYP2C9 and CYP2C19, so a meaningful rise in phenytoin is unlikely. Interaction is largely theoretical.
How serious is the interaction between Givinostat and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin levels and for signs of toxicity if clinically indicated.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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