Drug interactions
Glasdegib + Isoniazid
Severity: Moderate
Glasdegib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib is metabolized largely by CYP3A4 and can prolong the QT interval in a concentration-dependent way. Isoniazid may raise glasdegib exposure through modest CYP3A4 inhibition, which could increase QT risk and other adverse effects.
What this interaction means in plain words
Glasdegib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glasdegib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid weakly inhibits CYP3A4, which may raise glasdegib plasma concentrations.
What to do
Check baseline and periodic ECGs and electrolytes, including potassium and magnesium. Consider an alternative antituberculosis regimen if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Glasdegib with Isoniazid?
MediHelp rates the interaction as moderate. Glasdegib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glasdegib is metabolized largely by CYP3A4 and can prolong the QT interval in a concentration-dependent way. Isoniazid may raise glasdegib exposure through modest CYP3A4 inhibition, which could increase QT risk and other adverse effects.
How serious is the interaction between Glasdegib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and periodic ECGs and electrolytes, including potassium and magnesium. Consider an alternative antituberculosis regimen if QTc lengthens.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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