Drug interactions
Glecaprevir / pibrentasvir + Hydrochlorothiazide-telmisartan
Severity: Moderate
Glecaprevir / pibrentasvir and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit OATP1B1/3, P-gp and BCRP, which can raise telmisartan exposure. This may increase telmisartan effects such as hypotension, though the effect is not expected to be large.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of hepatic OATP1B1/3 uptake and intestinal P-gp/BCRP efflux by glecaprevir and pibrentasvir increases telmisartan concentrations.
What to do
Monitor blood pressure and renal function during hepatitis C therapy. Reduce the telmisartan dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit OATP1B1/3, P-gp and BCRP, which can raise telmisartan exposure. This may increase telmisartan effects such as hypotension, though the effect is not expected to be large.
How serious is the interaction between Glecaprevir / pibrentasvir and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during hepatitis C therapy. Reduce the telmisartan dose if hypotension occurs.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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