Drug interactions
Glecaprevir / pibrentasvir + Ketoconazole
Severity: Moderate
Glecaprevir / pibrentasvir and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may increase glecaprevir and pibrentasvir exposure. Increased concentrations raise the risk of adverse effects including liver enzyme elevations.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ketoconazole inhibits CYP3A4 and P-glycoprotein, which contribute to the disposition of both agents.
What to do
No dose adjustment is required by labeling, but monitor liver tests and for adverse effects during combined use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Ketoconazole?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole may increase glecaprevir and pibrentasvir exposure. Increased concentrations raise the risk of adverse effects including liver enzyme elevations.
How serious is the interaction between Glecaprevir / pibrentasvir and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required by labeling, but monitor liver tests and for adverse effects during combined use.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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