Drug interactions
Glecaprevir / pibrentasvir + Ledipasvir-sofosbuvir
Severity: Moderate
Glecaprevir / pibrentasvir and Ledipasvir-sofosbuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
These are two pan-genotypic or genotype-specific hepatitis C regimens with overlapping P-gp and BCRP inhibition. Combining them offers no therapeutic rationale and may increase exposure to each.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mutual inhibition of P-gp and BCRP raises exposure of both regimens.
What to do
Avoid combining the two regimens; choose a single DAA regimen and monitor for adverse effects if overlap is unavoidable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Ledipasvir-sofosbuvir?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. These are two pan-genotypic or genotype-specific hepatitis C regimens with overlapping P-gp and BCRP inhibition. Combining them offers no therapeutic rationale and may increase exposure to each.
How serious is the interaction between Glecaprevir / pibrentasvir and Ledipasvir-sofosbuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two regimens; choose a single DAA regimen and monitor for adverse effects if overlap is unavoidable.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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