Drug interactions
Glecaprevir / pibrentasvir + Lidocaine
Severity: Minor
Glecaprevir / pibrentasvir and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and may slightly raise lidocaine exposure. The clinical effect is expected to be small because lidocaine is not a sensitive P-gp substrate.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
P-glycoprotein inhibition by glecaprevir and pibrentasvir may reduce efflux of lidocaine and increase its exposure.
What to do
No dose adjustment is usually needed for local anesthetic use. When lidocaine is given systemically or at high doses, monitor for signs of toxicity such as CNS symptoms and arrhythmia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Lidocaine?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-glycoprotein and may slightly raise lidocaine exposure. The clinical effect is expected to be small because lidocaine is not a sensitive P-gp substrate.
How serious is the interaction between Glecaprevir / pibrentasvir and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed for local anesthetic use. When lidocaine is given systemically or at high doses, monitor for signs of toxicity such as CNS symptoms and arrhythmia.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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