Drug interactions
Glecaprevir / pibrentasvir + Lorlatinib
Severity: Major
Glecaprevir / pibrentasvir and Lorlatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may lower glecaprevir and pibrentasvir exposure, risking reduced antiviral efficacy and hepatitis C treatment failure.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Lorlatinib induces CYP3A4 and may also induce P-glycoprotein, increasing clearance of the antivirals.
What to do
Avoid the combination if possible, since inducers are not recommended with this regimen. Use an alternative HCV regimen or defer HCV treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Lorlatinib?
MediHelp rates the interaction as major. Glecaprevir / pibrentasvir and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lorlatinib may lower glecaprevir and pibrentasvir exposure, risking reduced antiviral efficacy and hepatitis C treatment failure.
How serious is the interaction between Glecaprevir / pibrentasvir and Lorlatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, since inducers are not recommended with this regimen. Use an alternative HCV regimen or defer HCV treatment.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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