Drug interactions
Glecaprevir / pibrentasvir + Metformin-pioglitazone
Severity: Minor
Glecaprevir / pibrentasvir and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir is an OATP1B1/1B3 substrate and pibrentasvir a P-gp substrate, but pioglitazone is not a recognized significant inhibitor of these transporters. A clinically meaningful rise in exposure is not expected.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical weak transporter or metabolic inhibition; not well established.
What to do
No dose adjustment is needed; monitor glucose as HCV treatment may change glycemic control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir is an OATP1B1/1B3 substrate and pibrentasvir a P-gp substrate, but pioglitazone is not a recognized significant inhibitor of these transporters. A clinically meaningful rise in exposure is not expected.
How serious is the interaction between Glecaprevir / pibrentasvir and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor glucose as HCV treatment may change glycemic control.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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