Drug interactions
Glecaprevir / pibrentasvir + Morphine
Severity: Minor
Glecaprevir / pibrentasvir and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit intestinal P-glycoprotein, and morphine is a P-gp substrate, so morphine exposure may rise modestly. This could increase opioid effects such as sedation and respiratory depression, although the effect is expected to be small.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of P-glycoprotein efflux by glecaprevir and pibrentasvir may increase morphine absorption and reduce its efflux.
What to do
No routine dose change is needed; watch for excess sedation or slowed breathing when starting the antiviral regimen, and reduce the morphine dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Morphine?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit intestinal P-glycoprotein, and morphine is a P-gp substrate, so morphine exposure may rise modestly. This could increase opioid effects such as sedation and respiratory depression, although the effect is expected to be small.
How serious is the interaction between Glecaprevir / pibrentasvir and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for excess sedation or slowed breathing when starting the antiviral regimen, and reduce the morphine dose if these occur.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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