Drug interactions
Glecaprevir / pibrentasvir + Nilotinib
Severity: Moderate
Glecaprevir / pibrentasvir and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both nilotinib and glecaprevir/pibrentasvir interact with P-glycoprotein, so each could modestly increase the other's exposure. The clinical impact is uncertain and likely small.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mutual inhibition of P-glycoprotein-mediated efflux.
What to do
Monitor for nilotinib adverse effects including QTc prolongation and for hepatic parameters. No empiric dose change is generally required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Nilotinib?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both nilotinib and glecaprevir/pibrentasvir interact with P-glycoprotein, so each could modestly increase the other's exposure. The clinical impact is uncertain and likely small.
How serious is the interaction between Glecaprevir / pibrentasvir and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nilotinib adverse effects including QTc prolongation and for hepatic parameters. No empiric dose change is generally required.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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