Drug interactions
Glecaprevir / pibrentasvir + Oxcarbazepine
Severity: Major
Glecaprevir / pibrentasvir and Oxcarbazepine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a CYP3A4 and P-gp inducer and may substantially lower glecaprevir and pibrentasvir exposure. This can lead to reduced antiviral efficacy and treatment failure or resistance.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Induction of CYP3A4 and P-glycoprotein increases clearance of both antivirals.
What to do
Avoid the combination and choose an alternative anticonvulsant such as levetiracetam where possible. If unavoidable, monitor HCV response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Oxcarbazepine?
MediHelp rates the interaction as major. Glecaprevir / pibrentasvir and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxcarbazepine is a CYP3A4 and P-gp inducer and may substantially lower glecaprevir and pibrentasvir exposure. This can lead to reduced antiviral efficacy and treatment failure or resistance.
How serious is the interaction between Glecaprevir / pibrentasvir and Oxcarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative anticonvulsant such as levetiracetam where possible. If unavoidable, monitor HCV response closely.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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