Drug interactions
Glecaprevir / pibrentasvir + Pantoprazole
Severity: Minor
Glecaprevir / pibrentasvir and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pantoprazole may modestly increase exposure to glecaprevir/pibrentasvir via efflux transporters, while the antiviral combination may raise levels of pantoprazole. Labeling indicates that PPIs can be used with the antiviral combination without dose adjustment.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mutual inhibition of P-gp and BCRP efflux transporters.
What to do
No dose adjustment is required. Monitor for adverse effects of either drug if symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glecaprevir / pibrentasvir and Pantoprazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Pantoprazole?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pantoprazole may modestly increase exposure to glecaprevir/pibrentasvir via efflux transporters, while the antiviral combination may raise levels of pantoprazole. Labeling indicates that PPIs can be used with the antiviral combination without dose adjustment.
How serious is the interaction between Glecaprevir / pibrentasvir and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor for adverse effects of either drug if symptoms arise.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
