Drug interactions
Glecaprevir / pibrentasvir + Pazopanib
Severity: Moderate
Glecaprevir / pibrentasvir and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-gp, BCRP and OATP1B1/3, so pazopanib exposure may increase. Pazopanib inhibits OATP1B1 and may also raise glecaprevir levels. Pazopanib hepatotoxicity may be of particular concern in patients treated for hepatitis C.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-gp/BCRP by the antivirals raises pazopanib exposure, and OATP1B1 inhibition by pazopanib may raise glecaprevir levels.
What to do
Monitor liver enzymes closely and watch for pazopanib adverse effects, reducing the dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Pazopanib?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-gp, BCRP and OATP1B1/3, so pazopanib exposure may increase. Pazopanib inhibits OATP1B1 and may also raise glecaprevir levels. Pazopanib hepatotoxicity may be of particular concern in patients treated for hepatitis C.
How serious is the interaction between Glecaprevir / pibrentasvir and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely and watch for pazopanib adverse effects, reducing the dose if toxicity occurs.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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