Drug interactions
Glecaprevir / pibrentasvir + Quinine
Severity: Moderate
Glecaprevir / pibrentasvir and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both quinine and glecaprevir/pibrentasvir inhibit P-glycoprotein and may raise each other's concentrations. The effect on quinine could increase cinchonism and QT risk, while higher HCV drug levels are usually well tolerated.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mutual inhibition of P-glycoprotein efflux transport.
What to do
Monitor for quinine adverse effects such as tinnitus and QT prolongation. No empiric dose changes are needed for the HCV regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Quinine?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both quinine and glecaprevir/pibrentasvir inhibit P-glycoprotein and may raise each other's concentrations. The effect on quinine could increase cinchonism and QT risk, while higher HCV drug levels are usually well tolerated.
How serious is the interaction between Glecaprevir / pibrentasvir and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine adverse effects such as tinnitus and QT prolongation. No empiric dose changes are needed for the HCV regimen.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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