Drug interactions
Glecaprevir / pibrentasvir + Sulphasalazine
Severity: Moderate
Glecaprevir / pibrentasvir and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit BCRP and P-glycoprotein in the gut and may increase exposure to sulfasalazine, a BCRP substrate. This could increase sulfasalazine adverse effects.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of intestinal BCRP efflux increases sulfasalazine absorption.
What to do
Monitor for sulfasalazine adverse effects during the HCV treatment course and reduce the dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Sulphasalazine?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit BCRP and P-glycoprotein in the gut and may increase exposure to sulfasalazine, a BCRP substrate. This could increase sulfasalazine adverse effects.
How serious is the interaction between Glecaprevir / pibrentasvir and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sulfasalazine adverse effects during the HCV treatment course and reduce the dose if toxicity develops.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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