Drug interactions
Glecaprevir / pibrentasvir + Sunitinib
Severity: Minor
Glecaprevir / pibrentasvir and Sunitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib may inhibit P-gp and BCRP, transporters that handle glecaprevir and pibrentasvir. Their exposure could increase, though the clinical effect is probably limited.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Sunitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of P-gp/BCRP efflux of glecaprevir and pibrentasvir by sunitinib.
What to do
No dose change is generally needed; monitor for hepatic adverse effects and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Sunitinib?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Sunitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sunitinib may inhibit P-gp and BCRP, transporters that handle glecaprevir and pibrentasvir. Their exposure could increase, though the clinical effect is probably limited.
How serious is the interaction between Glecaprevir / pibrentasvir and Sunitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for hepatic adverse effects and tolerability.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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