Drug interactions
Glecaprevir / pibrentasvir + Tamoxifen
Severity: Minor
Glecaprevir / pibrentasvir and Tamoxifen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tamoxifen inhibits P-glycoprotein and may modestly increase exposure to glecaprevir and pibrentasvir, which are P-gp substrates. The clinical impact is expected to be small.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Tamoxifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Tamoxifen inhibits P-glycoprotein efflux of glecaprevir and pibrentasvir.
What to do
No dose adjustment is required; monitor for hepatic adverse effects as usual during HCV treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Tamoxifen?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Tamoxifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tamoxifen inhibits P-glycoprotein and may modestly increase exposure to glecaprevir and pibrentasvir, which are P-gp substrates. The clinical impact is expected to be small.
How serious is the interaction between Glecaprevir / pibrentasvir and Tamoxifen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor for hepatic adverse effects as usual during HCV treatment.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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