Drug interactions
Glecaprevir / pibrentasvir + Tolvaptan
Severity: Moderate
Glecaprevir / pibrentasvir and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and may increase tolvaptan exposure. This could cause excessive aquaresis or too rapid a rise in serum sodium.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of intestinal P-gp efflux increases tolvaptan absorption and exposure.
What to do
Monitor serum sodium and fluid status during the HCV treatment course. Reduce tolvaptan dose if exaggerated response occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Tolvaptan?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-glycoprotein and may increase tolvaptan exposure. This could cause excessive aquaresis or too rapid a rise in serum sodium.
How serious is the interaction between Glecaprevir / pibrentasvir and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and fluid status during the HCV treatment course. Reduce tolvaptan dose if exaggerated response occurs.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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