Drug interactions
Glibenclamide + Nelfinavir
Severity: Moderate
Glibenclamide and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir, like other protease inhibitors, can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of glyburide. Glycemic control can deteriorate after starting nelfinavir.
What this interaction means in plain words
Glibenclamide and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glibenclamide belongs to Endocrine; Nelfinavir belongs to Anti Virals.
Why it happens
Protease inhibitor-induced insulin resistance opposes the glucose-lowering effect of glyburide.
What to do
Monitor blood glucose after starting nelfinavir. Adjust the glyburide dose or add other antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Glibenclamide with Nelfinavir?
MediHelp rates the interaction as moderate. Glibenclamide and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir, like other protease inhibitors, can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of glyburide. Glycemic control can deteriorate after starting nelfinavir.
How serious is the interaction between Glibenclamide and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting nelfinavir. Adjust the glyburide dose or add other antidiabetic therapy as needed.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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