Drug interactions
Glibenclamide + Propranolol
Severity: Moderate
Glibenclamide and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol can hide the adrenergic warning signs of hypoglycemia and prolong its duration. Glyburide has a long action, so hypoglycemia may be significant.
What this interaction means in plain words
Glibenclamide and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glibenclamide belongs to Endocrine; Propranolol belongs to Cardiovascular.
Why it happens
Non-selective beta-blockade suppresses adrenergic counter-regulation and glycogenolysis, and reduces insulin secretion.
What to do
Increase blood glucose monitoring and educate the patient on sweating as the remaining warning sign. Consider a cardioselective beta-blocker if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glibenclamide with Propranolol?
MediHelp rates the interaction as moderate. Glibenclamide and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol can hide the adrenergic warning signs of hypoglycemia and prolong its duration. Glyburide has a long action, so hypoglycemia may be significant.
How serious is the interaction between Glibenclamide and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase blood glucose monitoring and educate the patient on sweating as the remaining warning sign. Consider a cardioselective beta-blocker if possible.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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